When you scratch your chin, wring your hands, wrinkle your nose, or swallow too much, Dr. Cal Lightman knows you're lying. He doesn't just think so, he knows so, because he's taken his exceptional skills of observation to become the foremost deception expert in the
country. Being a human lie detector, Cal can uncover the deepest secrets and crack the hardest cases. More accurate than any polygraph test, he knows when those in front of him are being less than forthcoming, be they family, friends, or complete strangers.

Cal heads up a private agency that, together with his team, are contracted by the FBI, local police, law firms, corporations, and private individuals when they hit roadblocks in their searches for the truth.

Lie To Me probes how people can deceive themselves just as easily as they deceive others, and explores the idea that there's nothing more revealing than when we choose to tell the truth and when we decide to lie.